HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular accumulation of adenosine and subsequent activation of the ADORA2B receptor play important roles in regulating inflammation and fibrosis in IPF. Additionally, alternatively activated macrophages (AAMs) expressing ADO...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Philip, Kemly, Mills, Tingting Weng, Davies, Jonathan, Chen, Ning-Yuan, Karmouty-Quintana, Harry, Luo, Fayong, Molina, Jose G., Amione-Guerra, Javier, Sinha, Neeraj, Guha, Ashrith, Eltzschig, Holger K., Blackburn, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636704/
https://ncbi.nlm.nih.gov/pubmed/28701304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700219R
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