Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis

BACKGROUND AND PURPOSE: Group III pulmonary hypertension (PH) is a highly lethal and widespread lung disorder that is a common complication in idiopathic pulmonary fibrosis (IPF) where it is considered to be the single most significant predictor of mortality. While increased levels of hyaluronan hav...

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Publicado en:Br J Pharmacol
Autores principales: Collum, Scott D, Chen, Ning‐Yuan, Hernandez, Adriana M, Hanmandlu, Ankit, Sweeney, Heather, Mertens, Tinne C J, Weng, Tingting, Luo, Fayong, Molina, Jose G, Davies, Jonathan, Horan, Ian P, Morrell, Nick W, Amione‐Guerra, Javier, Al‐Jabbari, Odeaa, Youker, Keith, Sun, Wenchao, Rajadas, Jayakumar, Bollyky, Paul L, Akkanti, Bindu H, Jyothula, Soma, Sinha, Neeraj, Guha, Ashrith, Karmouty‐Quintana, Harry
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595757/
https://ncbi.nlm.nih.gov/pubmed/28688167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13947
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