Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years. Pulmonary hypertension (PH) is a frequently fatal complication of CPFE. Despite this dismal prognosis, no curative...

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Vydáno v:Dis Model Mech
Hlavní autoři: Collum, Scott D., Molina, Jose G., Hanmandlu, Ankit, Bi, Weizhen, Pedroza, Mesias, Mertens, Tinne C. J., Wareing, Nancy, Wei, Wang, Wilson, Cory, Sun, Wenchao, Rajadas, Jayakumar, Bollyky, Paul L., Philip, Kemly M., Ren, Dewei, Thandavarayan, Rajarajan A., Bruckner, Brian A., Xia, Yang, Blackburn, Michael R., Karmouty-Quintana, Harry
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550050/
https://ncbi.nlm.nih.gov/pubmed/31036697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038711
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