Transforming growth factor β1 alters the 3′-UTR of mRNA to promote lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by the pathological remodeling of air sacs as a result of excessive accumulation of extracellular matrix (ECM) proteins, but the mechanism governing the robust protein expression is poorly understood. Our recent findings demonstr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ko, Junsuk, Mills, Tingting, Huang, Jingjing, Chen, Ning-yuan, Mertens, Tinne C. J., Collum, Scott D., Lee, Garam, Xiang, Yu, Han, Leng, Zhou, Yang, Lee, Chun Geun, Elias, Jack A., Jyothula, Soma S. K., Rajagopal, Keshava, Karmouty-Quintana, Harry, Blackburn, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816088/
https://ncbi.nlm.nih.gov/pubmed/31488543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009148
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