Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM

Natural IgM binds to glomerular epitopes in several progressive kidney diseases. Previous work has shown that IgM also binds within the glomerulus after ischemia/reperfusion (I/R) but does not fully activate the complement system. Factor H is a circulating complement regulatory protein, and congenit...

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Publicat a:Eur J Immunol
Autors principals: Goetz, Lindsey, Laskowski, Jennifer, Renner, Brandon, Pickering, Matthew C., Kulik, Liudmila, Klawitter, Jelena, Stites, Erik, Christians, Uwe, van der Vlag, Johan, Ravichandran, Kameswaran, Holers, V. Michael, Thurman, Joshua M.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992014/
https://ncbi.nlm.nih.gov/pubmed/29389016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747240
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