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Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus
Humoral autoimmunity is central to the development of systemic lupus erythematosus (SLE). Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, des...
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| 發表在: | J Immunol |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
AAI
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6900485/ https://ncbi.nlm.nih.gov/pubmed/31732528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900620 |
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