Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus

Humoral autoimmunity is central to the development of systemic lupus erythematosus (SLE). Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, des...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Kulik, Liudmila, Laskowski, Jennifer, Renner, Brandon, Woolaver, Rachel, Zhang, Lian, Lyubchenko, Taras, You, Zhiying, Thurman, Joshua M., Holers, V. Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2019
Schlagworte:
Autoimmunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900485/
https://ncbi.nlm.nih.gov/pubmed/31732528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900620
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