Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus

Humoral autoimmunity is central to the development of systemic lupus erythematosus (SLE). Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, des...

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書目詳細資料
發表在:J Immunol
Main Authors: Kulik, Liudmila, Laskowski, Jennifer, Renner, Brandon, Woolaver, Rachel, Zhang, Lian, Lyubchenko, Taras, You, Zhiying, Thurman, Joshua M., Holers, V. Michael
格式: Artigo
語言:Inglês
出版: AAI 2019
主題:
Autoimmunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900485/
https://ncbi.nlm.nih.gov/pubmed/31732528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900620
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