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IgM Contributes to Glomerular Injury in FSGS

Glomerular IgM and C3 deposits frequently accompany idiopathic FSGS and secondary glomerulosclerosis, but it is unknown whether IgM activates complement, possibly contributing to the pathogenesis of these diseases. We hypothesized that IgM natural antibody binds to neoepitopes exposed in the glomeru...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Strassheim, Derek, Renner, Brandon, Panzer, Sarah, Fuquay, Richard, Kulik, Liudmila, Ljubanović, Danica, Holers, V. Michael, Thurman, Joshua M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582199/
https://ncbi.nlm.nih.gov/pubmed/23393315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020187
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