IgM Contributes to Glomerular Injury in FSGS

Glomerular IgM and C3 deposits frequently accompany idiopathic FSGS and secondary glomerulosclerosis, but it is unknown whether IgM activates complement, possibly contributing to the pathogenesis of these diseases. We hypothesized that IgM natural antibody binds to neoepitopes exposed in the glomeru...

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Bibliografiske detaljer
Main Authors: Strassheim, Derek, Renner, Brandon, Panzer, Sarah, Fuquay, Richard, Kulik, Liudmila, Ljubanović, Danica, Holers, V. Michael, Thurman, Joshua M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2013
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582199/
https://ncbi.nlm.nih.gov/pubmed/23393315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020187
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