Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM

Natural IgM binds to glomerular epitopes in several progressive kidney diseases. Previous work has shown that IgM also binds within the glomerulus after ischemia/reperfusion (I/R) but does not fully activate the complement system. Factor H is a circulating complement regulatory protein, and congenit...

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Xehetasun bibliografikoak
Argitaratua izan da:Eur J Immunol
Egile Nagusiak: Goetz, Lindsey, Laskowski, Jennifer, Renner, Brandon, Pickering, Matthew C., Kulik, Liudmila, Klawitter, Jelena, Stites, Erik, Christians, Uwe, van der Vlag, Johan, Ravichandran, Kameswaran, Holers, V. Michael, Thurman, Joshua M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992014/
https://ncbi.nlm.nih.gov/pubmed/29389016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747240
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