Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Species differences in renal drug transporters continue to plague drug development with animal models failing to adequately predict renal drug toxicity. For example, adefovir, a renally excreted antiviral drug, failed clinical studies for human immunodeficiency virus due to pronounced nephrotoxicity...

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Bibliografski detalji
Izdano u:Mol Pharmacol
Glavni autori: Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D., Stahl, Simone H., Fenner, Katherine S., Giacomini, Kathleen M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987998/
https://ncbi.nlm.nih.gov/pubmed/29720497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.111153
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