Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155

Persistent viral infections and tumors drive development of exhausted T (T(EX)) cells. In these settings, T(EX) cells establish an important host-pathogen or host-tumor stalemate. However, T(EX) cells erode over time, leading to loss of pathogen or cancer containment. We identified microRNA (miR)-15...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Stelekati, Erietta, Chen, Zeyu, Manne, Sasikanth, Kurachi, Makoto, Ali, Mohammed-Alkhatim, Lewy, Keith, Cai, Zhangying, Nzingha, Kito, McLane, Laura M., Hope, Jennifer L., Fike, Adam J., Katsikis, Peter D., Wherry, E. John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986283/
https://ncbi.nlm.nih.gov/pubmed/29768211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.038
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