Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

Increasing evidence suggests that synaptic functions of the amyloid precursor protein (APP), which is key to Alzheimer pathogenesis, may be carried out by its secreted ectodomain (APPs). The specific roles of APPsα and APPsβ fragments, generated by non‐amyloidogenic or amyloidogenic APP processing,...

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Publicado en:EMBO J
Main Authors: Richter, Max C, Ludewig, Susann, Winschel, Alex, Abel, Tobias, Bold, Charlotte, Salzburger, Leonie R, Klein, Susanne, Han, Kang, Weyer, Sascha W, Fritz, Ann‐Kristina, Laube, Bodo, Wolfer, David P, Buchholz, Christian J, Korte, Martin, Müller, Ulrike C
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983155/
https://ncbi.nlm.nih.gov/pubmed/29661886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798335
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