Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used organotypic hippocampal cultures to investigate the specific role(s) of APP family members and...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Weyer, Sascha W, Zagrebelsky, Marta, Herrmann, Ulrike, Hick, Meike, Ganss, Lennard, Gobbert, Julia, Gruber, Morna, Altmann, Christine, Korte, Martin, Deller, Thomas, Müller, Ulrike C
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023627/
https://ncbi.nlm.nih.gov/pubmed/24684730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-36
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы