Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used organotypic hippocampal cultures to investigate the specific role(s) of APP family members and...

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Detalhes bibliográficos
Main Authors: Weyer, Sascha W, Zagrebelsky, Marta, Herrmann, Ulrike, Hick, Meike, Ganss, Lennard, Gobbert, Julia, Gruber, Morna, Altmann, Christine, Korte, Martin, Deller, Thomas, Müller, Ulrike C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023627/
https://ncbi.nlm.nih.gov/pubmed/24684730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-36
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