Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used organotypic hippocampal cultures to investigate the specific role(s) of APP family members and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Weyer, Sascha W, Zagrebelsky, Marta, Herrmann, Ulrike, Hick, Meike, Ganss, Lennard, Gobbert, Julia, Gruber, Morna, Altmann, Christine, Korte, Martin, Deller, Thomas, Müller, Ulrike C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023627/
https://ncbi.nlm.nih.gov/pubmed/24684730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-36
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge