APPsα rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons

Alterations in Ca(2+) homeostasis have been reported in several in vitro and in vivo studies using mice expressing the Alzheimer’s disease–associated transgenes, presenilin and the amyloid precursor protein (APP). While intense research focused on amyloid-β–mediated functions on neuronal Ca(2+) hand...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Ludewig, Susann, Herrmann, Ulrike, Michaelsen-Preusse, Kristin, Metzdorf, Kristin, Just, Jennifer, Bold, Charlotte, Müller, Ulrike C., Korte, Martin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2021
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256088/
https://ncbi.nlm.nih.gov/pubmed/34172567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011506118
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