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APPsα rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons
Alterations in Ca(2+) homeostasis have been reported in several in vitro and in vivo studies using mice expressing the Alzheimer’s disease–associated transgenes, presenilin and the amyloid precursor protein (APP). While intense research focused on amyloid-β–mediated functions on neuronal Ca(2+) hand...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8256088/ https://ncbi.nlm.nih.gov/pubmed/34172567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011506118 |
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