APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously, we generated APPsα knock-in (KI) mice expressing solely the secreted ectodomain APPsα. Here, we generated double...

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Detalhes bibliográficos
Main Authors: Weyer, Sascha W, Klevanski, Maja, Delekate, Andrea, Voikar, Vootele, Aydin, Dorothee, Hick, Meike, Filippov, Mikhail, Drost, Natalia, Schaller, Kristin L, Saar, Martina, Vogt, Miriam A, Gass, Peter, Samanta, Ayan, Jäschke, Andres, Korte, Martin, Wolfer, David P, Caldwell, John H, Müller, Ulrike C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117640/
https://ncbi.nlm.nih.gov/pubmed/21522131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.119
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