Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

Increasing evidence suggests that synaptic functions of the amyloid precursor protein (APP), which is key to Alzheimer pathogenesis, may be carried out by its secreted ectodomain (APPs). The specific roles of APPsα and APPsβ fragments, generated by non‐amyloidogenic or amyloidogenic APP processing,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Richter, Max C, Ludewig, Susann, Winschel, Alex, Abel, Tobias, Bold, Charlotte, Salzburger, Leonie R, Klein, Susanne, Han, Kang, Weyer, Sascha W, Fritz, Ann‐Kristina, Laube, Bodo, Wolfer, David P, Buchholz, Christian J, Korte, Martin, Müller, Ulrike C
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983155/
https://ncbi.nlm.nih.gov/pubmed/29661886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798335
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares