An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within physiologically relevant concentrations, phenylalanine, alanine, tryptophan, methionine, valine, and proline act as inhibitors, while histidine and serin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem J
Prif Awduron: Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980995/
https://ncbi.nlm.nih.gov/pubmed/29748232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180171
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