M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites. Phenylalanine stabilizes an inactive T-state tetrameric conformer and inhibits M2PYK with an IC(50) value of...

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Detalhes bibliográficos
Main Authors: Morgan, Hugh P., O’Reilly, Francis J., Wear, Martin A., O’Neill, J. Robert, Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625322/
https://ncbi.nlm.nih.gov/pubmed/23530218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217157110
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