An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within physiologically relevant concentrations, phenylalanine, alanine, tryptophan, methionine, valine, and proline act as inhibitors, while histidine and serin...

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Veröffentlicht in:Biochem J
Hauptverfasser: Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980995/
https://ncbi.nlm.nih.gov/pubmed/29748232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180171
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