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An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within physiologically relevant concentrations, phenylalanine, alanine, tryptophan, methionine, valine, and proline act as inhibitors, while histidine and serin...
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| Izdano u: | Biochem J |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Portland Press Ltd.
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980995/ https://ncbi.nlm.nih.gov/pubmed/29748232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180171 |
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