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4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H(3) Receptor Antagonist: Further Structure–Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation

Presynaptic histamine H(3) receptors (H(3)R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in the central nervous system (CNS). The extracellular levels of several neurotransmitters are enhanced by H(3)R antagonists, and there is a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Olszewska, Beata, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979327/
https://ncbi.nlm.nih.gov/pubmed/29671795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19041243
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