Φορτώνει......
Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H(3) receptor antagonists
Previously, we have shown that 1-substituted-[4-(7-phenoxyheptylpiperazin-1-yl)butyl]guanidine with electron withdrawing substituents at position 4 in the benzyl moiety exhibits high in vitro affinities toward the guinea pig jejunal histamine H(3) receptor with pA(2) ranging from 8.49 to 8.43. Here,...
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| Τόπος έκδοσης: | Medchemcomm |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Royal Society of Chemistry
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6390473/ https://ncbi.nlm.nih.gov/pubmed/30881612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00527c |
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