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Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H(3) receptor antagonists
Previously, we have shown that 1-substituted-[4-(7-phenoxyheptylpiperazin-1-yl)butyl]guanidine with electron withdrawing substituents at position 4 in the benzyl moiety exhibits high in vitro affinities toward the guinea pig jejunal histamine H(3) receptor with pA(2) ranging from 8.49 to 8.43. Here,...
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| Vydáno v: | Medchemcomm |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Royal Society of Chemistry
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6390473/ https://ncbi.nlm.nih.gov/pubmed/30881612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00527c |
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