Guanidine Derivatives: How Simple Structural Modification of Histamine H(3)R Antagonists Has Led to the Discovery of Potent Muscarinic M(2)R/M(4)R Antagonists

[Image: see text] This article describes the discovery of novel potent muscarinic receptor antagonists identified during a search for more active histamine H(3) receptor (H(3)R) ligands. The idea was to replace the flexible seven methylene linker with a semirigid 1,4-cyclohexylene or p-phenylene sub...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Staszewski, Marek, Nelic, Dominik, Jończyk, Jakub, Dubiel, Mariam, Frank, Annika, Stark, Holger, Bajda, Marek, Jakubik, Jan, Walczyński, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291587/
https://ncbi.nlm.nih.gov/pubmed/34100603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00237
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