Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model

Gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft (PDOX) model. The PDOX model was established in th...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Miyake, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Miyake, Masuyo, Igarashi, Kentaro, Zhang, Zhiying, Murakami, Takashi, Li, Yunfeng, Nelson, Scott D., Elliott, Irmina, Russell, Tara, Singh, Arun, Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969563/
https://ncbi.nlm.nih.gov/pubmed/29334307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1423223
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