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The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy

The aim of the present study was to determine the usefulness of a patient-derived orthotopic xenograft (PDOX) nude-mouse model of a doxorubicin-resistant metastatic Ewing’s sarcoma, with a unique combination of a FUS-ERG fusion and CDKN2A deletion, to identify effective drugs for third-line chemothe...

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Foilsithe in:Oncotarget
Main Authors: Miyake, Kentaro, Murakami, Takashi, Kiyuna, Tasuku, Igarashi, Kentaro, Kawaguchi, Kei, Miyake, Masuyo, Li, Yunfeng, Nelson, Scott D., Dry, Sarah M., Bouvet, Michael, Elliott, Irmina A., Russell, Tara A., Singh, Arun S., Eckardt, Mark A., Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732717/
https://ncbi.nlm.nih.gov/pubmed/29262551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20789
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