Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model

Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss and FUS-ERG fusion was implanted in the right chest wall of nude mice to establish a patient-derived orthotopic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Murakami, Takashi, Singh, Arun S., Kiyuna, Tasuku, Dry, Sarah M., Li, Yunfeng, James, Aaron W., Igarashi, Kentaro, Kawaguchi, Kei, DeLong, Jonathan C., Zhang, Yong, Hiroshima, Yukihiko, Russell, Tara, Eckardt, Mark A., Yanagawa, Jane, Federman, Noah, Matsuyama, Ryusei, Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216960/
https://ncbi.nlm.nih.gov/pubmed/27286459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9879
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