Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model

Methionine dependence is due to the overuse of methionine for aberrant transmethylation reactions in cancer. Methionine dependence may be the only general metabolic defect in cancer. In order to exploit methionine dependence for therapy, our laboratory previously cloned L-methionine α-deamino-γ-merc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Murakami, Takashi, Li, Shukuan, Han, Qinghong, Tan, Yuying, Kiyuna, Tasuku, Igarashi, Kentaro, Kawaguchi, Kei, Hwang, Ho Kyoung, Miyake, Kentaro, Singh, Arun S., Nelson, Scott D., Dry, Sarah M., Li, Yunfeng, Hiroshima, Yukihiko, Lwin, Thinzar M., DeLong, Jonathan C., Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482604/
https://ncbi.nlm.nih.gov/pubmed/28404944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15823
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