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Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model

An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant methioninase (rMETase). The present study used a p...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Kawaguchi, Kei, Igarashi, Kentaro, Li, Shukuan, Han, Qinghong, Tan, Yuying, Kiyuna, Tasuku, Miyake, Kentaro, Murakami, Takashi, Chmielowski, Bartosz, Nelson, Scott D., Russell, Tara A., Dry, Sarah M., Li, Yunfeng, Unno, Michiaki, Eilber, Fritz C., Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689627/
https://ncbi.nlm.nih.gov/pubmed/29156737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20231
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