Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention

The elevated methionine (MET) use by cancer cells is termed MET dependence and may be the only known general metabolic defect in cancer. Targeting MET by recombinant methioninase (rMETase) can arrest the growth of cancer cells in vitro and in vivo. We previously reported that rMETase, administrated...

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Bibliografische gegevens
Gepubliceerd in:Cell Cycle
Hoofdauteurs: Kawaguchi, Kei, Han, Qinghong, Li, Shukuan, Tan, Yuying, Igarashi, Kentaro, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Chmielowski, Bartosz, Nelson, Scott D., Russell, Tara A., Dry, Sarah M., Li, Yunfeng, Singh, Arun S., Eckardt, Mark A., Unno, Michiaki, Eilber, Fritz C., Hoffman, Robert M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2018
Onderwerpen:
Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914727/
https://ncbi.nlm.nih.gov/pubmed/29187018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1405195
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