Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

BACKGROUND: Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mouse models...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Kiyuna, Tasuku, Tome, Yasunori, Murakami, Takashi, Kawaguchi, Kei, Igarashi, Kentaro, Miyake, Kentaro, Miyake, Masuyo, Li, Yunfeng, Nelson, Scott D., Dry, Sarah M., Singh, Arun S., Russell, Tara A., Elliott, Irmina, Singh, Shree Ram, Kanaya, Fuminori, Eilber, Fritz C., Hoffman, Robert M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102848/
https://ncbi.nlm.nih.gov/pubmed/30126369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4703-0
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