A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology

In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy. Osteosarcoma resected from the patient was imp...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Igarashi, Kentaro, Murakami, Takashi, Kawaguchi, Kei, Kiyuna, Tasuku, Miyake, Kentaro, Zhang, Yong, Nelson, Scott D., Dry, Sarah M., Li, Yunfeng, Yanagawa, Jane, Russell, Tara A., Singh, Arun S., Tsuchiya, Hiroyuki, Elliott, Irmina, Eilber, Fritz C., Hoffman, Robert M.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617490/
https://ncbi.nlm.nih.gov/pubmed/28977930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19095
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