Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic

In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella typhimurium A1-R (S. typhimurium A1-R), which decoys chemoresistant quiescent cancer cells to cycle, and recombinant methioninase (r...

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Vydáno v:Cell Cycle
Hlavní autoři: Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Li, Shukuan, Han, Qinghong, Tan, Yuying, Zhao, Ming, Li, Yunfeng, Nelson, Scott D., Dry, Sarah M., Singh, Arun S., Elliott, Irmina A., Russell, Tara A., Eckardt, Mark A., Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Tsuchiya, Hiroyuki, Eilber, Fritz C., Hoffman, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
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Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969544/
https://ncbi.nlm.nih.gov/pubmed/29374999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1431596
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