Bitopic Binding Mode of an M(1) Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

The realization of the therapeutic potential of targeting the M(1) muscarinic acetylcholine receptor (mAChR) for the treatment of cognitive decline in Alzheimer’s disease has prompted the discovery of M(1) mAChR ligands showing efficacy in alleviating cognitive dysfunction in both rodents and humans...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Bradley, Sophie J., Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J., Thompson, Karen J., Dwomoh, Louis, Sanger, Helen E., Crabtree, Michael D., Brooke, Simon M., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Broad, Lisa M., Tobin, Andrew B., Langmead, Christopher J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963591/
https://ncbi.nlm.nih.gov/pubmed/29695609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.111872
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