DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

[Image: see text] Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarin...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407913/
https://ncbi.nlm.nih.gov/pubmed/30868140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00012
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