Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in addition to NTH...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Limpose, Kristin L, Trego, Kelly S, Li, Zhentian, Leung, Sara W, Sarker, Altaf H, Shah, Jason A, Ramalingam, Suresh S, Werner, Erica M, Dynan, William S, Cooper, Priscilla K, Corbett, Anita H, Doetsch, Paul W
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961185/
https://ncbi.nlm.nih.gov/pubmed/29522130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky162
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires