Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in addition to NTH...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Limpose, Kristin L, Trego, Kelly S, Li, Zhentian, Leung, Sara W, Sarker, Altaf H, Shah, Jason A, Ramalingam, Suresh S, Werner, Erica M, Dynan, William S, Cooper, Priscilla K, Corbett, Anita H, Doetsch, Paul W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961185/
https://ncbi.nlm.nih.gov/pubmed/29522130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky162
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