Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in addition to NTH...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Limpose, Kristin L, Trego, Kelly S, Li, Zhentian, Leung, Sara W, Sarker, Altaf H, Shah, Jason A, Ramalingam, Suresh S, Werner, Erica M, Dynan, William S, Cooper, Priscilla K, Corbett, Anita H, Doetsch, Paul W
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961185/
https://ncbi.nlm.nih.gov/pubmed/29522130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky162
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky