Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer

Base excision repair (BER), which is initiated by DNA N-glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. The NTHL1 glycosylase, which excises DNA base damage caused by reactive oxygen species, is thought to be a tumor suppressor. However, in addition to NTH...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Limpose, Kristin L, Trego, Kelly S, Li, Zhentian, Leung, Sara W, Sarker, Altaf H, Shah, Jason A, Ramalingam, Suresh S, Werner, Erica M, Dynan, William S, Cooper, Priscilla K, Corbett, Anita H, Doetsch, Paul W
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961185/
https://ncbi.nlm.nih.gov/pubmed/29522130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky162
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