Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability

DNA trinucleotide repeat (TNR) expansion underlies several neurodegenerative disorders including Huntington's disease (HD). Accumulation of oxidized DNA bases and their inefficient processing by base excision repair (BER) are among the factors suggested to contribute to TNR expansion. In this s...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Cilli, Piera, Ventura, Ilenia, Minoprio, Anna, Meccia, Ettore, Martire, Alberto, Wilson, Samuel H., Bignami, Margherita, Mazzei, Filomena
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914090/
https://ncbi.nlm.nih.gov/pubmed/26980281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw170
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