Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability

DNA trinucleotide repeat (TNR) expansion underlies several neurodegenerative disorders including Huntington's disease (HD). Accumulation of oxidized DNA bases and their inefficient processing by base excision repair (BER) are among the factors suggested to contribute to TNR expansion. In this s...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Cilli, Piera, Ventura, Ilenia, Minoprio, Anna, Meccia, Ettore, Martire, Alberto, Wilson, Samuel H., Bignami, Margherita, Mazzei, Filomena
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914090/
https://ncbi.nlm.nih.gov/pubmed/26980281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw170
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