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Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two distinct mechanisms by which naturally occurring oxidized dNTPs and therapeutic dNTPs inhibit telomerase-medi...
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| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7576608/ https://ncbi.nlm.nih.gov/pubmed/33082336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19115-y |
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