Understanding the role of the Q338H MUTYH variant in oxidative damage repair

The MUTYH DNA–glycosylase is indirectly engaged in the repair of the miscoding 7,8-dihydro-8-oxo-2′-deoxyguanine (8-oxodG) lesion by removing adenine erroneously incorporated opposite the oxidized purine. Inherited biallelic mutations in the MUTYH gene are responsible for a recessive syndrome, the M...

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Bibliographic Details
Main Authors: Turco, Eleonora, Ventura, Ilenia, Minoprio, Anna, Russo, Maria Teresa, Torreri, Paola, Degan, Paolo, Molatore, Sara, Ranzani, Guglielmina Nadia, Bignami, Margherita, Mazzei, Filomena
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627602/
https://ncbi.nlm.nih.gov/pubmed/23460202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt130
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