DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1

Although inflammation-induced peripheral sensitization oftentimes resolves as an injury heals, this sensitization can be pathologically maintained and contribute to chronic inflammatory pain. Numerous inflammatory mediators increase the production of reactive oxygen (ROS) and nitrogen species (RNS)...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuroscience
Auteurs principaux: Fehrenbacher, Jill C., Guo, Chunlu, Kelley, Mark R., Vasko, Michael R.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954980/
https://ncbi.nlm.nih.gov/pubmed/28965839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2017.09.039
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