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DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1

Although inflammation-induced peripheral sensitization oftentimes resolves as an injury heals, this sensitization can be pathologically maintained and contribute to chronic inflammatory pain. Numerous inflammatory mediators increase the production of reactive oxygen (ROS) and nitrogen species (RNS)...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Fehrenbacher, Jill C., Guo, Chunlu, Kelley, Mark R., Vasko, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954980/
https://ncbi.nlm.nih.gov/pubmed/28965839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2017.09.039
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