APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Peripheral neuropathy is one of the major side effects of treatment with the anticancer drug, cisplatin. One proposed mechanism for this neurotoxicity is the formation of platinum adducts in sensory neurons that could contribute to DNA damage. Although this damage is largely repaired by nuclear exci...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mutat Res
Auteurs principaux: Kim, Hyun-Suk, Guo, Chunlu, Thompson, Eric L., Jiang, Yanlin, Kelley, Mark R., Vasko, Michael R., Lee, Suk-Hee
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554977/
https://ncbi.nlm.nih.gov/pubmed/26164266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.06.010
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