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APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Peripheral neuropathy is one of the major side effects of treatment with the anticancer drug, cisplatin. One proposed mechanism for this neurotoxicity is the formation of platinum adducts in sensory neurons that could contribute to DNA damage. Although this damage is largely repaired by nuclear exci...

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Bibliografiske detaljer
Udgivet i:Mutat Res
Main Authors: Kim, Hyun-Suk, Guo, Chunlu, Thompson, Eric L., Jiang, Yanlin, Kelley, Mark R., Vasko, Michael R., Lee, Suk-Hee
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554977/
https://ncbi.nlm.nih.gov/pubmed/26164266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.06.010
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