APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Peripheral neuropathy is one of the major side effects of treatment with the anticancer drug, cisplatin. One proposed mechanism for this neurotoxicity is the formation of platinum adducts in sensory neurons that could contribute to DNA damage. Although this damage is largely repaired by nuclear exci...

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Vydáno v:Mutat Res
Hlavní autoři: Kim, Hyun-Suk, Guo, Chunlu, Thompson, Eric L., Jiang, Yanlin, Kelley, Mark R., Vasko, Michael R., Lee, Suk-Hee
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554977/
https://ncbi.nlm.nih.gov/pubmed/26164266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.06.010
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