APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Peripheral neuropathy is one of the major side effects of treatment with the anticancer drug, cisplatin. One proposed mechanism for this neurotoxicity is the formation of platinum adducts in sensory neurons that could contribute to DNA damage. Although this damage is largely repaired by nuclear exci...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mutat Res
Egile Nagusiak: Kim, Hyun-Suk, Guo, Chunlu, Thompson, Eric L., Jiang, Yanlin, Kelley, Mark R., Vasko, Michael R., Lee, Suk-Hee
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554977/
https://ncbi.nlm.nih.gov/pubmed/26164266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.06.010
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