Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo

Herpes simplex virus 1 (HSV-1) establishes a lifelong latent infection in host peripheral neurons, including the neurons of the trigeminal ganglia (TG). HSV-1 can reactivate from neurons to cause recurrent infection. During latency, the insulator protein CTCF occupies DNA binding sites on the HSV-1...

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Bibliographic Details
Published in:J Virol
Main Authors: Washington, Shannan D., Edenfield, Samantha I., Lieux, Caroline, Watson, Zachary L., Taasan, Sean M., Dhummakupt, Adit, Bloom, David C., Neumann, Donna M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952164/
https://ncbi.nlm.nih.gov/pubmed/29514910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00173-18
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