In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency

During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence s...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Watson, Zachary L., Washington, Shannan D., Phelan, Dane M., Lewin, Alfred S., Tuli, Sonal S., Schultz, Gregory S., Neumann, Donna M., Bloom, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069208/
https://ncbi.nlm.nih.gov/pubmed/29875240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00812-18
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