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Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity
Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer’s disease (AD). Our previous results indicated that amyloid beta (Aβ) peptides and inflammatio...
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| Udgivet i: | Mol Neurobiol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5948241/ https://ncbi.nlm.nih.gov/pubmed/28698968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0646-8 |
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